Unprecedented copper-mediated oxidative demethylation of propionamides via bidentate-chelation assistance.
نویسندگان
چکیده
A copper-mediated directed demethylation of propionamides has been developed. This reaction proceeds predominantly at the α-methyl groups of aliphatic amides with high efficiency and provides a unique tool for the direct cleavage of unactivated C(sp(3))-C(sp(3)) bonds. The directing groups can be smoothly removed to afford the corresponding alkyl carboxylic acids.
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ورودعنوان ژورنال:
- Chemical communications
دوره 52 6 شماره
صفحات -
تاریخ انتشار 2016